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麻醉監(jiān)測||腦電圖與意識(shí)


以下文章來源于小麻哥的日常 ,作者兩只小綿羊



麻醉監(jiān)測||腦電圖與意識(shí)(圖1)


摘要譯文(供參考)


靜息狀態(tài)腦電圖的臨界性預(yù)測麻醉過程中的擾動(dòng)復(fù)雜性和意識(shí)水平


意識(shí)已被提出由處于臨界狀態(tài)的電生理學(xué)模式支持,這是一種表現(xiàn)出自適應(yīng)計(jì)算特性、最大復(fù)雜模式和對擾動(dòng)的發(fā)散敏感性的動(dòng)態(tài)機(jī)制。


在此,我們研究了接受丙泊酚、氙氣或氯胺酮全身麻醉的健康受試者靜息狀態(tài)腦電圖的動(dòng)態(tài)特性。


然后,我們研究了這些動(dòng)態(tài)特性與擾動(dòng)復(fù)雜性指數(shù)(PCI)的關(guān)系,該指數(shù)在獨(dú)立于行為的意識(shí)檢測中顯示出顯著的高靈敏度。


所有參與者在麻醉下都沒有反應(yīng),而意識(shí)只有在氯胺酮麻醉(以生動(dòng)的夢的形式)時(shí)才能保持,這使得無反應(yīng)和無意識(shí)之間的實(shí)驗(yàn)分離成為可能。


我們估計(jì)(i)雪崩臨界,(ii)混亂,和(iii)臨界相關(guān)的測量,發(fā)現(xiàn)無意識(shí)狀態(tài)的特征是遠(yuǎn)離活動(dòng)傳播的邊緣和混亂的邊緣。


然后我們能夠預(yù)測個(gè)體受試者的PCI(即PCI最大值我們的結(jié)果建立了PCI和臨界性之間的緊密聯(lián)系,并為臨界性在意識(shí)出現(xiàn)中的作用提供了進(jìn)一步的證據(jù)。


原文摘要


Criticality of resting-state EEG predicts perturbational complexity and level of consciousness during anesthesia


Consciousness has been proposed to be supported by electrophysiological patterns poised at criticality, a dynamical regime which exhibits adaptive computational properties, maximally complex patterns and divergent sensitivity to perturbation. Here, we investigated dynamical properties of the resting-state electroencephalogram of healthy subjects undergoing general anesthesia with propofol, xenon or ketamine. We then studied the relation of these dynamic properties with the perturbational complexity index (PCI), which has shown remarkably high sensitivity in detecting consciousness independent of behavior. All participants were unresponsive under anesthesia, while consciousness was retained only during ketamine anesthesia (in the form of vivid dreams)., enabling an experimental dissociation between unresponsiveness and unconsciousness. We estimated (i) avalanche criticality, (ii) chaoticity, and (iii) criticality-related measures, and found that states of unconsciousness were characterized by a distancing from both the edge of activity propagation and the edge of chaos. We were then able to predict individual subjects' PCI (i.e., PCImax) with a mean absolute error below 7%. Our results establish a firm link between the PCI and criticality and provide further evidence for the role of criticality in the emergence of consciousness.








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